Ozone treatment has long been used to treat injuries and aid systemic detoxification. Ozone treatment is now being used as a potential novel adjuvant therapy to enhance fertility. Both men's and women's reproductive systems are supported by this alternative therapeutic treatment. Ozone treatment may be used at any age. Still, it is beneficial for women over 35 trying to conceive, as it helps to maintain a healthy vagina and healthy ovaries, which increases the likelihood of successful IVF and pregnancy. When used by qualified specialists with specialised equipment, ozone treatment offers several advantages without negative effects. (1) A frequent ailment known as pelvic inflammatory disease (PID) affects the uterus, surrounding pelvic tissues, and fallopian tubes (producing obstruction and tubal infertility). It is marked by infection and inflammation of the female upper genital tract. Ectopic pregnancy and persistent pelvic discomfort are other symptoms of PID. According to research by An Wi et al., injecting female rats with ozone through their vaginal cavity significantly inhibited prostate inflammation. (2)  Infertility can result from endometrial and embryonic immune responses being disrupted by uterine inflammation and bacterial infections. According to a study conducted on cows, intrauterine ozone therapy boosted postpartum fertility rates. (3) Urine collecting in the cranial region of the vagina results in urine pooling around the cervix and can induce endometritis and vaginitis, which can lead to infertility and reduced embryo viability. (4) In one research, 1219 cows with uterovaginal infections were treated with saline (control), and antibiotics (streptomycin). The group that received ozone therapy flush had the shortest period of days open, the fewest number of inseminations until (5) ovarian torsion—which is a prevalent issue among women in their reproductive years—causes decreased blood flow to the ovary, which results in egg mortality and decreased fertility. Patients may receive treatment by having their adnexa detruded in order to protect their ovary, although this has drawbacks such as ischemia/reperfusion damage. Lactic acid and hypoxanthine levels rise during ischemia, and free oxygen radicals are produced during reperfusion, which results in aberrant pathologic alterations in ovarian tissue. (6,7) Postoperative intraabdominal adhesions caused by ischemia or peritoneal injury may result in pelvic discomfort and maybe infertility. While ozone therapy decreases inflammation and enhances antioxidant enzyme activities such as glutathione peroxidase and SOD activity by modifying reactive oxygen species production, it is well known that oxidative stress plays a significant role in adhesion formation. Bipolar coagulation on the uterine horns and matching pelvic sidewall parietal peritoneum was used in one study to assess the effectiveness of ozone therapy in a female Wistar rat model of experimental uterine adhesion (EUA). (8)

References

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